Prophets Isaiah and Jeremiah foretold the complete demise of Babylon in the Hebrew Bible. Their prophecies were realized with the conquest of Babylon by Cyrus the Great as part of the Medo-Persian empire in 539 B.C.E., with significant aspects like Babylon’s waters drying up and its defense ceasing combat. The fall and lasting desolation of Babylon served as evidence of the Bible’s predictive accuracy and divine origin, reinforcing its reliability and the notion of divine inspiration behind its writing.